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No. 11 · Sexual wellness
PT-141 for Women
Bremelanotide injection, as needed
PT-141 is the research name for bremelanotide, a medicine that acts on brain pathways involved in sexual desire rather than on blood flow. The brand-name version is FDA-approved for premenopausal women with acquired, generalized low sexual desire; the compounded injection prescribed here is not FDA-approved and is $235 a month or $505 a quarter.
For low sexual desire in premenopausal women.
| Option | Monthly | Quarterly, 3 months | Start |
|---|---|---|---|
| PT-141 injection | $235 | $505about $168 a month | Start |
Prices include the online visit, licensed provider review, medication and shipping. Quarterly plans ship three months at a time. Cancel or pause anytime. Available online in Detroit, Metro Detroit and across Michigan, and in other states where our providers are licensed.
Online visits for Detroit, Metro Detroit and Michigan. Questions first? Email support@hoolongevity.com or call (586) 321-3377.
Who it's for
- Premenopausal women with low desire that is persistent and distressing
- Women whose provider has reviewed other causes, such as medications, stress or relationship factors
Not for
- Uncontrolled high blood pressure or known heart disease
- Pregnancy
- Use after menopause is off-label, with less evidence, and is not what this page promotes
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Complete a private online visit
A licensed provider reviews your history and blood pressure, if appropriate
Your prescription ships in discreet packaging
Follow your label exactly; the approved product is used at least 45 minutes before sexual activity, no more than once in 24 hours
What's included
- Online visit and licensed provider review
- Compounded PT-141 injection
- Supplies and discreet shipping
- Messaging with your care team
Important safety information
- Nausea is the most common side effect: in the approved product's trials about 40% of women had nausea, compared with about 1% on placebo.
- It can cause a temporary rise in blood pressure and a drop in heart rate after each dose.
- Darkening of the gums and skin on the face or breasts has been reported, and may not fully fade.
- Tell your provider about every medication, especially oral naltrexone.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated November 3, 2026.
Questions, answered
Straight answers about PT-141 for Women.
What is PT-141 and how does it work for women?
PT-141 is the research name for bremelanotide, a medicine that acts on melanocortin receptors in the brain involved in sexual desire rather than on blood flow. A brand-name bremelanotide autoinjector (Vyleesi) is approved by the FDA for premenopausal women with acquired, generalized hypoactive sexual desire disorder, while compounded versions are not FDA approved. A licensed provider will review whether it is appropriate for you.
Can I use PT-141 after menopause?
The FDA approval for bremelanotide covers only premenopausal women, so use after menopause is off-label and has less supporting evidence. For low desire after menopause, a licensed provider may also discuss other approaches, such as treating vaginal dryness or, in some cases, testosterone. Your provider will review your history before recommending anything.
Does PT-141 make you nauseous? How bad is it?
Nausea is the most common side effect: in the trials for the approved product, about 40% of women had nausea compared with about 1% on placebo, and it can occasionally be severe. Flushing, headache and injection site reactions were also common. Ask your licensed provider how to reduce nausea and when to seek help.
Can PT-141 darken your skin?
Yes, darkening of the gums and of skin on the face and breasts has been reported with bremelanotide, and in trials it occurred more often in Black women. It may not fully fade after stopping, and using more doses than prescribed raises the risk. Tell your licensed provider if you notice new dark patches.
Can I take PT-141 with my other medications, like naltrexone or birth control?
Bremelanotide can slow stomach emptying and may lower the levels of some medicines taken by mouth, and its label specifically cautions about oral naltrexone. Share every medication and supplement you take, including birth control, during your online visit so a licensed provider can check for interactions.
Sources
- FDA, Drug Trials Snapshots: Vyleesi (bremelanotide)
- FDA, Compounding and the FDA: Questions and Answers
Reviewed November 3, 2026.
Read more
Health GuideHow to Give Yourself a Subcutaneous Injection
Subcutaneous injections go into the fatty layer under the skin, usually the belly or thigh, with a small needle. Follow the step-by-step directions that come with your prescription, rotate sites, and never reuse or share needles.
IntimacyHow to Use PT-141 (Bremelanotide): Timing and Side Effects
PT-141 is taken as needed, injected under the skin at least 45 minutes before sexual activity according to the FDA-approved label. Nausea is the most common side effect, and it can briefly raise blood pressure.
IntimacyLow Libido in Women: Causes and Treatment Options
Low desire is common and has many causes, including stress, sleep, relationships, medications and hormones. Options range from addressing those causes and sex therapy to FDA-approved medicines such as bremelanotide (PT-141) and flibanserin for some premenopausal women.
Ready to start?
A licensed provider reviews your online visit and decides whether PT-141 for Women is right for you.